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Aniba rosaeodora, also known as rosewood, brazilian rosewood, bois de rose and pau-rosa, is a species of Magnoliid tree in the family Lauraceae.
Although sometimes wrongly referred to as rosewood this name is totally misleading, it is no tree of the genus Dalbergia. It grows in parts of the tropical rainforest of South America. It is an endangered species that sees exploitation for its essential oil. |
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linalool
An abundant (~90%) essential oil of the leaves of Aniba rosaeodora that is used in the traditional medicine of the Peruvian and Brazilian Amazon for its effects on the central nervous system, such as :
Additionally, linalool has :
Several studies have demonstrated a gamma of anti-infectious activity like :
The anticancer mechanisms of action of linalool in hepatocellular carcinoma (HCC) HepG2 cells were recently revealed by Rodenak-Kladniew et al.
According to these researchers, linalool in a dose-dependently blocked cell proliferation by inducing G0/G1 cell cycle arrest, through Cdk4 and cyclin A downregulation, p21 and p27 upregulation, and apoptosis, characterized by mitochondrial membrane potential loss, caspase-3 activation, poly(ADP-ribose) polymerase cleavage, and DNA fragmentation.
- sedative,
- anticonvulsant, and
- antidepressant.
Additionally, linalool has :
- anti-inflammatory,
- anticancer,
- antihyperlipidemic,
- antinociceptive,
- analgesic,
- anxiolytic, and
- neuroprotective properties.
Several studies have demonstrated a gamma of anti-infectious activity like :
- antiviral,
- antibacterial,
- antifungal, and
- antileishmanial.
The anticancer mechanisms of action of linalool in hepatocellular carcinoma (HCC) HepG2 cells were recently revealed by Rodenak-Kladniew et al.
According to these researchers, linalool in a dose-dependently blocked cell proliferation by inducing G0/G1 cell cycle arrest, through Cdk4 and cyclin A downregulation, p21 and p27 upregulation, and apoptosis, characterized by mitochondrial membrane potential loss, caspase-3 activation, poly(ADP-ribose) polymerase cleavage, and DNA fragmentation.
Figure 4. - Anticancer mechanisms of action of linalool in hepatocellular carcinoma (HCC) HepG2 cells.
